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See-through mice aid anatomy study

Posted: August 1, 2014 at 2:49 a.m.

NEW YORK — Researchers have found a way to make see-through mice, but you won’t find these critters scampering in your kitchen.

The transparent rodents aren’t alive, and they’re for research only, to help scientists study fine details of anatomy.

Before they are treated with chemicals, the animals are euthanized and their skin removed. Researchers made their inner organs transparent but not their bones.

The results look like a rodent-shaped block of gelatin with the organs held in place by connective tissue and a gel used in the procedure.

Mice are mainstays of biomedical research because much of their basic biology is similar to ours, and they can be altered in ways that simulate human diseases.

Scientists have been able to make tissues transparent to some degree for a century, and in recent years several new methods have been developed. Last year, for example, a technique that produced see-through mouse brains made headlines. Such treatments reveal far more detail than X-rays or MRI exams could deliver.

It should be useful for projects like mapping the details of the nervous system or the spread of cancer within lab animals, said Viviana Gradinaru of the California Institute of Technology, senior author of a paper describing the work.

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