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story.lead_photo.caption How influenza gets in - Photo by Arkansas Democrat-Gazette / SOURCE: Centers for Disease Control and Prevention survey figures cited by The Commonwealth Fund

According to the misery map of influenza activity in the United States, there's a good chance that you or someone you know has experienced, or will experience, this year's strain, H3N2.

The map, from the Centers for Disease Control and Prevention, shows there was widespread flu-like illnesses reported in all the states and Puerto Rico during the week that ended Jan. 13. And the current flu vaccine seems not to match the virus -- in Australia, where flu season comes earlier, it was estimated to be only 10 percent effective.

Hospitals nationwide report clogged emergency rooms, and pharmacies are experiencing shortages of over-the-counter and prescription flu remedies. Flu season does not end until May.

Vulnerable patients with weakened immune systems should consult their doctors, as should anyone who begins to have trouble breathing or feels faint. But for otherwise healthy individuals, the best strategy is to understand how flu affects your body, and practice self-care accordingly.

Flu is spread predominantly by droplets in the air. So if you are within 6 feet of someone who is infected, you are likely to breathe in their exhalations. The virus will then latch onto the mucous membranes that line your nose, your throat and your bronchial tubes (see graphic).

Next, the invaders hijack the epithelial cells that make up the mucous membranes, taking over their metabolic machinery, to replicate and make even more virus, which infects adjacent cells.

This initial phase takes one to four days.

"The more you inhale, the shorter the incubation period," said Dr. William Schaffner, an infectious disease specialist at Vanderbilt University School of Medicine in Nashville, Tenn. "In the beginning, you don't feel sick. You don't even know it's there."

As the virus colonizes your respiratory tract, your body starts to figure out something is amiss and rallies its immunologic troops in an inflammatory response, releasing proteins called interferons -- because they interfere with alien invaders. Interferons flood your bloodstream and set up camp in mucus, prompting more proteins called cytokines to join the battle. These protein soldiers circulate throughout your body, ready to rumble.

"Paradoxically, our own soldiers created for the fight are what cause us to have symptoms," Schaffner said.

"War creates damage and so you get fever and a headache and muscular aches and pains," which you experience as the abrupt and intense opening salvos of the flu. These early symptoms are usually what distinguishes the flu from a normal cold.

The achiness and fever also signal that you need to start drinking a lot of fluids. The battle royal being waged inside you will dehydrate you more than you think. You may notice that your urine will get darker and you will have to go less often. Experts say to make sure you drink a cup or so of water or other liquid every hour, avoiding alcoholic and caffeinated beverages.

Drinking fluids will diminish the headache and also bolster your immune response because your protein soldiers are conveyed via bodily fluids. Dehydration hampers their movement.

It is one reason people tend to want soup when they're sick and may crave watery fruits.


While you may feel rotten all over, the real battle is going on in your respiratory tract where the virus is localized.

When the war is winding down, you stop feeling achy and feverish, but you have residual inflammation in your throat, sinuses and bronchial tubes. All those cells lining your mucous membranes have been damaged and are like weeping sores, Schaffner said. That is why your nose is runny and you start to sneeze and cough to clear out the detritus.

Given this, over-the-counter medications that suppress your cough and dry your sinuses may not be the best idea.

"Certainly there is the thought that you don't want to suppress a cough too much or dry out your nasal passages because you want to get rid of the infection," said Dr. Tara Vijayan, an assistant clinical professor in the division of infectious diseases at the University of California, Los Angeles, David Geffen School of Medicine. "There's a balance for sure. I don't think you should suffer unnecessarily, but you need to weigh the true benefit."

Although you want to rest, lying flat all the time collapses the lungs so you cannot cough as efficiently, trapping bacteria in your respiratory tract. If the virus destroys enough cells in your bronchial tubes, it creates openings for bacteria to get into your lungs, which can lead to pneumonia, which could become life-threatening.


The CDC recommends people who are hospitalized or at high risk for complications of the flu, such as older patients, pregnant women and those who are otherwise immunocompromised, take the anti-viral drug oseltamivir, sold under the brand name Tamiflu, because observational data indicate it might reduce the likelihood of death.

Other researchers, including those at the nonprofit study reviewer Cochrane, disagree, saying that there is not enough evidence to support taking oseltamivir or its chemical cousin zanamivir (brand name Relenza).

They question the wisdom of spending billions stockpiling the drugs as many countries, including the United States, began doing amid fears of a future flu pandemic in the mid-2000s. Indeed, the World Health Organization last year downgraded oseltamivir from its list of essential medicines. It might or might not help, depending on which study you read.

For healthy people who get the flu, most researchers agree the data indicate oseltamivir taken within 48 hours of onset can reduce the duration by about two-thirds of a day. But at around $154 for a course of the medication, that may not be worthwhile, given that the side effects include stomach upset.


The CDC also still recommends getting this season's flu shot, despite its questionable prophylactic value, because it might reduce the severity of the flu should you contract it. In other years, against strains other than H3N2, flu shots have had reported effectiveness of 40 percent to 60 percent.

But beyond that, rest, fluids, not staying horizontal all day and perhaps also letting in fresh air and sunlight are the best things you can do for yourself. To prevent friends, family members and colleagues from getting sick, keep to yourself until 48 hours after your fever has subsided and you're feeling better.

While you could continue to cough for weeks, Schaffner said, you probably are not infectious. Just annoying.

ActiveStyle on 01/29/2018

Print Headline: The flu attacks the body by air and hijacks cells

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