Drug in Ebola tests bound for Liberia

Tuesday, August 12, 2014

MONROVIA, Liberia -- Liberia announced Monday that it would soon receive doses of an experimental Ebola drug and give it to two sick doctors, making them the first Africans to receive some of the scarce treatment in a spiraling outbreak.

The U.S. government confirmed that it had put Liberian officials in touch with the maker of ZMapp and referred additional questions to Mapp Biopharmaceutical Inc. In a statement, the California-based company said that in responding to a request from an unidentified West African country, it had run out of its supply of the treatment.

The news comes as anger is growing over the fact that the only people to receive the experimental treatment so far have been Westerners: two Americans and a Spaniard, all of whom were evacuated to their home countries from Liberia.

"It certainly looks bad that only three Westerners have gotten the drug while most of the people with Ebola are African," said Art Caplan, director of bioethics at NYU Langone Medical Center, earlier Monday.

Late Monday, the World Health Organization said 1,013 people had died in the Ebola outbreak in West Africa. Authorities have recorded 1,848 suspected, probable or confirmed cases of the disease, the U.N. health agency said. The updated tally includes figures from Thursday through Saturday when 52 more people died and 69 more were infected.

There is no Ebola vaccine or treatment available, but there are several in development besides ZMapp. That treatment is so new that it hasn't been tested for safety or effectiveness in humans. And the company has said it would take months to produce even modest quantities.

It was unclear how much of the treatment would be sent to Liberia.

"The U.S. Government assisted in connecting the Government of Liberia with the manufacturer," the U.S. Department of Health and Human Services said in a statement. "Since the drug was shipped for use outside the U.S., appropriate export procedures had to be followed."

In the past few weeks, the experimental drug was given to two American aid workers -- Dr. Kent Brantly and Nancy Writebol -- diagnosed with the disease while working at a hospital that treated Ebola patients. On Monday, officials in Spain disclosed that the treatment was also given to a Spanish missionary priest who fell ill while working in Liberia.

The Americans are said to be improving, but there's no way to know whether the drug helped or if they are getting better on their own, as others have. About 40 percent of those infected with Ebola are surviving the current outbreak.

But some called for the untested drug to be given to Africans, too. The outbreak was first identified in March in Guinea, but it likely started months earlier. It has since spread to neighboring Liberia and Sierra Leone, and possibly to Nigeria.

Some used Twitter to demand that the drug be made available.

"We can't afford to be passive while many more die," said Aisha Dabo, a Senegalese-Gambian journalist who was tweeting using the hashtag "GiveUsTheSerum" on Monday. "That's why we raise our voice for the world to hear us."

The ethical dilemmas involved prompted the U.N. health agency to consult Monday with ethicists, infectious disease experts, patient representatives and the Doctors Without Borders group. Most participants in the closed teleconference were from developed countries, but Uganda and Senegal were represented.

The World Health Organization said it would discuss the results of the meeting at a news conference today.

Companies can provide experimental drugs on a "compassionate use" basis, usually after they have been fully tested in humans. The Food and Drug Administration approves such uses in the U.S. but has no authority overseas. Ultimately, the companies alone decide whether or not to share their products.

Spain's Health Ministry said it obtained ZMapp this weekend with company permission to treat Miguel Pajares, a 75-year-old priest evacuated from Liberia and placed in isolation Thursday.

"The medicine was imported from Geneva where there was one dose available in the context of an accord between the laboratory that developed the medicine, WHO and [Doctors Without Borders]," the ministry said, invoking a Spanish law permitting unauthorized medication for patients with life-threatening illnesses.

The treatment is aimed at boosting the immune system's efforts to fight off Ebola. It is made from antibodies grown inside tobacco plants.

Information for this article was contributed by Lauran Neergaard, Julie Pace, Ciaran Giles, Boubacar Diallo, Marc-Andre Boisvert and Bashir Adigun of The Associated Press.

A Section on 08/12/2014